Fator de crescimento nervoso

Fator de crescimento nervoso - com sigla (em inglês): NGF (de Nerve growth factor) é uma pequena proteína de secreção interna, importante para o crescimento, manutenção e sobrevivência de determinados neurônios (células nervosas). Também funciona como molécula de sinalização entre os neurônios. É um provável protótipo do fator de crescimento, dos quais foi um dos primeiros a ser descrito. Usado no singular trata de um fator específico, em contrapartida para o plural (fatores de crescimento nervoso), que se referem às neurotrofinas. Outros tipos de neurotrofinas conhecidos são o BNDF (Brain-Derived Neurotrophic Factor), a neurotrofina-3 (NT-3) e neurotrofina 4/5 (NT-4/5).

Factor de crescimento nervoso (polipéptido beta)
Dímero de NGF (a partir de PDB 1SG1)
Estruturas disponíveis PDB Busca de ortólogos: PDBe, RCSB Lista de códigos PDB 1SG1, 1WWW, 2IFG, 4EDW, 4EDX
Identificadores
Símbolos	NGF; Beta-NGF; HSAN5; NGFB
IDs externos	OMIM: 162030 MGI: 97321 HomoloGene: 1876 ChEMBL: 1649058 GeneCards: NGF Gene
Ontologia do gene Função molecular •receptor signaling protein activity •nerve growth factor receptor binding •growth factor activity Componente celular •extracellular region •extracellular space •endosome •Golgi lumen Processo biológico •activation of MAPKK activity •inflammatory response •transmembrane receptor protein tyrosine kinase signaling pathway •activation of phospholipase C activity •small GTPase mediated signal transduction •Ras protein signal transduction •peripheral nervous system development •memory •adult locomotory behavior •extrinsic apoptotic signaling pathway via death domain receptors •response to radiation •response to mechanical stimulus •response to ozone •positive regulation of gene expression •sensory perception of pain •positive regulation of protein autophosphorylation •nerve growth factor processing •response to lipopolysaccharide •response to nicotine •response to drug •positive regulation of apoptotic process •negative regulation of apoptotic process •regulation of cysteine-type endopeptidase activity involved in apoptotic process •response to peptide hormone •negative regulation of neuron apoptotic process •positive regulation of neuron differentiation •positive regulation of axon extension •negative regulation of cell cycle •regulation of neurotransmitter secretion •neurotrophin TRK receptor signaling pathway •phosphatidylinositol-mediated signaling •neuron projection morphogenesis •regulation of axonogenesis •positive regulation of axonogenesis •positive regulation of sequence-specific DNA binding transcription factor activity •response to glucocorticoid •positive regulation of neurotrophin TRK receptor signaling pathway •neuron apoptotic process •response to electrical stimulus •apoptotic signaling pathway •extrinsic apoptotic signaling pathway in absence of ligand •positive regulation of stem cell proliferation •negative regulation of type B pancreatic cell apoptotic process Sources: Amigo / QuickGO
Padrões de expressão do ARN
Mais dados de expressão
Ortólogos
Espécies	Humano	Rato
Entrez	4803	18049
Ensembl	ENSG00000134259	ENSMUSG00000027859
UniProt	P01138	P01139
RefSeq (mRNA)	NM_002506	NM_001112698
RefSeq (proteína)	NP_002497	NP_001106168
Localização (UCSC)	Chr 1: 115.83 – 115.88 Mb	Chr 3: 102.47 – 102.52 Mb
Busca PubMed	[1]	[2]