Recetor de estrogénio beta

ESR2
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	4J26, 1L2J, 1NDE, 1QKM, 1U3Q, 1U3R, 1U3S, 1U9E, 1X76, 1X78, 1X7B, 1X7J, 1YY4, 1YYE, 1ZAF, 2FSZ, 2GIU, 2I0G, 2JJ3, 2NV7, 2QTU, 2YJD, 2YLY, 2Z4B, 3OLL, 3OLS, 3OMO, 3OMP, 3OMQ, 4J24, 4ZI1
Identificadores
Nomes alternativos	ESR2, Receptor de estrogénio beta
IDs externos	OMIM: 601663 HomoloGene: 1100 GeneCards: ESR2
Targeted by Drug
	estradiol, dietilestilbestrol, estriol, estrona, etinilestradiol, genisteína, tamoxifeno, bisfenol A, lasofoxifene, bazedoxifeno, Raloxifeno, fosfestrol, acolbifene, erteberel, estramustine phosphate sodium, droloxifene
Ontologia genética
Função molecular	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity; • metal ion binding; • steroid hormone receptor activity; • steroid binding; • zinc ion binding; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • DNA binding; • sequence-specific DNA binding; • GO:0001105 transcription coactivator activity; • receptor antagonist activity; • lipid binding; • enzyme binding; • estrogen response element binding; • core promoter sequence-specific DNA binding; • estrogen receptor activity; • identical protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Componente celular	• mitocôndria; • núcleo celular; • cariolinfa; • extracellular region;
Processo biológico	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • negative regulation of cell growth; • transcription initiation from RNA polymerase II promoter; • positive regulation of DNA-binding transcription factor activity; • cell-cell signaling; • GO:0072468 transdução de sinal; • extracellular negative regulation of signal transduction; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:1901227 negative regulation of transcription by RNA polymerase II; • intracellular estrogen receptor signaling pathway; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cellular response to estradiol stimulus; • negative regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	; ; ; ;
	Mais dados de referência de expressão
Ortólogos
	2100
	n/a
	ENSG00000140009
	n/a
	Q92731
	n/a
NM_001040275; NM_001040276; NM_001214902; NM_001214903; NM_001271876;
	NM_001271877; NM_001291712; NM_001291723; NM_001437
	n/a
NP_001035365; NP_001201831; NP_001258805; NP_001258806; NP_001278641;
	NP_001278652; NP_001428
	n/a
	Wikidata
Ver/Editar Humano

Recetor de estrogénio beta (ERß), também denominado NR3A1 (recetor nuclear subfamília 3, grupo A, membro 1), é um dos dois principais tipos de recetores de estrogénio, um recetor nuclear que é ativado pela hormona estrogénio. Nos seres humanos, o ERß é codificado pelo gene ESR1 (recetor de estrogénio 1).^[3]^[4]^[5]