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Receptor metabotrópico de glutamato 3

O receptor metabotrópico de glutamato 3 é uma proteína que em seres humanos é codificada pelo gene GRM3.[1][2][3] Os receptores metabotrópicos de glutamato são uma família de receptores acoplados à proteína G.

Glutamate metabotropic receptor 3
Identificadores
Nomes alternativos
IDs externosGeneCards: [1]
Wikidata
Ver/Editar Humano

Interações

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O receptor metabotrópico de glutamato 3 mostrou interação com as proteínas GRIP1,[4] PICK1[4] e PPM1A.[5]

Referências

  1. ↑ Chad J. Swanson, Mark Bures, Michael P. Johnson, Anni-Maija Linden, James A. Monn & Darryle D. Schoepp. «Metabotropic glutamate receptors as novel targets for anxiety and stress disorders» (em inglês). fevereiro de 2005. Consultado em 1 de julho de 2010 
  2. ↑ Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (1997). «Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q». Genomics. 31 (2): 230–3. PMID 8824806. doi:10.1006/geno.1996.0036 
  3. ↑ «Entrez Gene: GRM3 glutamate receptor, metabotropic 3» 
  4. ↑ a b Hirbec, Hélène; Perestenko Olga, Nishimune Atsushi, Meyer Guido, Nakanishi Shigetada, Henley Jeremy M, Dev Kumlesh K (2002). «The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs». United States. J. Biol. Chem. 277 (18): 15221–4. ISSN 0021-9258. PMID 11891216. doi:10.1074/jbc.C200112200 
  5. ↑ Flajolet, Marc; Rakhilin Sergey, Wang Hong, Starkova Natalia, Nuangchamnong Nina, Nairn Angus C, Greengard Paul (2003). «Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3». United States. Proc. Natl. Acad. Sci. U.S.A. 100 (26): 16006–11. ISSN 0027-8424. PMC 307683 . PMID 14663150. doi:10.1073/pnas.2136600100 

Bibliografia

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  • Makoff A, Volpe F, Lelchuk R; et al. (1997). «Molecular characterization and localization of human metabotropic glutamate receptor type 3.». Brain Res. Mol. Brain Res. 40 (1): 55–63. PMID 8840013. doi:10.1016/0169-328X(96)00037-X 
  • Emile L, Mercken L, Apiou F; et al. (1997). «Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3.». Neuropharmacology. 35 (5): 523–30. PMID 8887960. doi:10.1016/0028-3908(96)84622-3 
  • Corti C, Sala CF, Yang F; et al. (2001). «Genomic organization of the human metabotropic glutamate receptor subtype 3.». J. Neurogenet. 14 (4): 207–25, 271. PMID 11342382. doi:10.3109/01677060009084499 
  • Corti C, Xuereb JH, Corsi M, Ferraguti F (2001). «Identification and characterization of the promoter region of the GRM3 gene.». Biochem. Biophys. Res. Commun. 286 (2): 381–7. PMID 11500049. doi:10.1006/bbrc.2001.5391 
  • Tomiyama M, Kimura T, Maeda T; et al. (2001). «Expression of metabotropic glutamate receptor mRNAs in the human spinal cord: implications for selective vulnerability of spinal motor neurons in amyotrophic lateral sclerosis.». J. Neurol. Sci. 189 (1-2): 65–9. PMID 11535235. doi:10.1016/S0022-510X(01)00561-5 
  • Rosemond E, Peltekova V, Naples M; et al. (2002). «Molecular determinants of high affinity binding to group III metabotropic glutamate receptors.». J. Biol. Chem. 277 (9): 7333–40. PMID 11744707. doi:10.1074/jbc.M110476200 
  • Martí SB, Cichon S, Propping P, Nöthen M (2002). «Metabotropic glutamate receptor 3 (GRM3) gene variation is not associated with schizophrenia or bipolar affective disorder in the German population.». Am. J. Med. Genet. 114 (1): 46–50. PMID 11840505. doi:10.1002/ajmg.1624 
  • Kitano J, Kimura K, Yamazaki Y; et al. (2002). «Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.». J. Neurosci. 22 (4): 1280–9. PMID 11850456 
  • Hirbec H, Perestenko O, Nishimune A; et al. (2002). «The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.». J. Biol. Chem. 277 (18): 15221–4. PMID 11891216. doi:10.1074/jbc.C200112200 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 
  • Scherer SW, Cheung J, MacDonald JR; et al. (2003). «Human chromosome 7: DNA sequence and biology.». Science. 300 (5620): 767–72. PMID 12690205. doi:10.1126/science.1083423 
  • Fujii Y, Shibata H, Kikuta R; et al. (2004). «Positive associations of polymorphisms in the metabotropic glutamate receptor type 3 gene (GRM3) with schizophrenia.». Psychiatr. Genet. 13 (2): 71–6. PMID 12782962. doi:10.1097/01.ypg.0000056682.82896.b0 
  • Aronica E, Gorter JA, Ijlst-Keizers H; et al. (2003). «Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins.». Eur. J. Neurosci. 17 (10): 2106–18. PMID 12786977. doi:10.1046/j.1460-9568.2003.02657.x 
  • Hillier LW, Fulton RS, Fulton LA; et al. (2003). «The DNA sequence of human chromosome 7.». Nature. 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782 
  • Flajolet M, Rakhilin S, Wang H; et al. (2004). «Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3.». Proc. Natl. Acad. Sci. U.S.A. 100 (26): 16006–11. PMC 307683 . PMID 14663150. doi:10.1073/pnas.2136600100 
  • Yao Y, Koo JC, Wells JW, Hampson DR (2004). «Expression of a truncated secreted form of the mGluR3 subtype of metabotropic glutamate receptor.». Biochem. Biophys. Res. Commun. 319 (2): 622–8. PMID 15178451. doi:10.1016/j.bbrc.2004.05.032 
  • Tang FR, Chia SC, Chen PM; et al. (2004). «Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.». Epilepsy Res. 59 (2-3): 167–80. PMID 15246118. doi:10.1016/j.eplepsyres.2004.04.002 
  • Egan MF, Straub RE, Goldberg TE; et al. (2004). «Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.». Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12604–9. PMC 515104 . PMID 15310849. doi:10.1073/pnas.0405077101 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504 


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